Dr. Lars Zender
Medical School, Medical School Hannover, Germany
Medical Doctor (MD), Medical School Hannover, Germany
Doctoral Thesis (Dr. med), Dept. of Gastroenterology & Hepatology (Director: Prof. Dr. M.P. Manns), Medical School Hannover, Hannover, Germany, Advisor : Prof. Dr. Stefan Kubicka.
Thesis topic: Characterization of molecular mechanisms of viral toxicity in mouse models of adenoviral hepatitis; Grade:
Selected publications, Dr. med. Lars Zender:
Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S,Luk JM, Schirmacher P, Richard McCombie W, Wigler M, Hicks J, Hannon GJ, Powers S, Lowe SW. An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell. 2008 Nov 28;135(5):852-64. Epub 2008 Nov 13.
Xue W*, Zender L, Miething C, Dickins R, Hernando E, Krizhanovsky V, Cordon Cardo C, Lowe SW. P53 Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007 Feb 8;445(7128):656-60.
(* both authors contributed equally to this work) [See also News & Views in the same issue].
Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 2006 Jun 30;125(7):1253-67 (see Editorial on page 1230).
Krizhanovsky V, Yon, M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW. Senescence of activated stellate cells limits liver fibrosis. Cell.: 134: 657-667, 2008
Zender L, Huetker S, Zender S, Liedtke C, Trautwein C, Malek N P, Manns M P, K