GASL-Award of the YAEL foundation

The GASL-Award of the YAEL foundation is granted each year at the occasion of the annual congress of the German Association for the Study of the Liver (GASL). The price, which is donated annually with 3,000 €, is awarded by the board and programme committee of the GASL to honour the best scientific publication of the previous year.

Laureate 2018

Dr. Abdo Mahli

Dr. Abdo Mahli

Academic Career
2016-current: Scientific Assistent at the Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany
2014-2016: Scientific Researcher (PostDoc) at the Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
2009-2013: PhD Student in the Department of Internal Medicine I at the University Hospital Regensburg in the Work group of Prof.Dr.med. Claus Hellerbrand (thesis defense to obtain Dr. rer. nat. degree in Dec 2013; rate: magna cum laude)

Education
2002-2007: Study of Pharmacy and Pharmaceutical Chemistry, University of Aleppo, Major: Pharmaceutical industry, Minors: botany and biochemistry (diploma in July 2007; rate: very good)

Awards
1. EASL Young Investigator Bursary (Full Bursary), (European Association for the Study of the Liver), Vienna, Austria (18-22.April.2015)
2. EASL Young Investigator Bursary (Registration Bursary), (European Association for the Study of the Liver), Barcelona, Spain (18-22.April.2012)
3. Travel Awards from Falk workshop for the Years (2012, 2013, 2014, 2016 and 2017)

Selected publications (with Dr. Mahli as first or corresponding author)
Original publications:
Mahli A, Saugspier M, Koch A, Sommer J, Dietrich P, Lee S, Thasler R, Schulze-Luehrmann J, Luehrmann A, Thasler WE, Müller M, Bosserhoff A, Hellerbrand C. (2017), ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis.
Gut.pii: gutjnl-2016-312485. doi: 10.1136/gutjnl-2016-312485. [Epub ahead of print].

Sommer J 2, Mahli A 2, Freese K, Schiergens TS, Kuecuekoktay FS, Teufel A, Thasler WE, Müller M, Bosserhoff AK, Hellerbrand C. (2016), Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice.
Oncotarget. 2016 Dec 30. doi: 10.18632/oncotarget.14371. 2: equal contribution.

Mahli A, Thasler WE, Patsenker E, Müller S, Stickel F, Müller M, Seitz HK, Cederbaum AI, Hellerbrand C. (2015), Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro. Oncotarget. 2015 Dec 8;6(39):41464-78. doi: 10.18632/oncotarget.6203.

Mahli A, Koch A, Czech B, Peterburs P, Lechner A, Haunschild J, Müller M and Hellerbrand C. (2015), Hepatoprotective effect of oral application of a silymarin extract in carbon tetrachloride-induced hepatotoxicity in rats.
Clinical PhytoscienceInternational Journal of Phytomedicine and Phytotherapy20151:5 DOI: 10.1186/s40816-015-0006-z.

Mahli A, Koch A, Freese K, Thasler WE, Bergheim I, Schönberger C, Bosserhoff A, Hellerbrand C.
Iso-Alpha Acids (IAA) from hops (Humulus lupulus) inhibit hepatic steatosis, inflammation and fibrosis (submitted).

Reviews:
Mahli A, Hellerbrand C. Alcohol and Obesity: A Dangerous Association for Fatty Liver Disease. Dig Dis. 2016;34 Suppl 1:32-9. doi: 10.1159/000447279.

Weiskirchen R 2, Mahli A 2, Weiskirchen S, Hellerbrand C. The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels. Front Physiol. 2015 May 6;6:140.doi:10.3389/fphys.2015.00140. 2: equal contribution.

 

Laureate 2017

 

Laureate 2016

 

Laureate 2015

 

Laureate 2014

 

Laureate 2013

 

Laureate 2012

 

Laureate 2011

 

Laureate 2010

 

Laureate 2009